oŠèŽ‘Ši—vŒ

š At least one year clinical training is required prior to taking this course.

At least two years clinical training is required prior to taking this course.

ž Students are required to have graduated from medical school.

@› Students are not required to have graduated from medical school.

Representative Investigator of the field.

Course

Field

Subjedt

Professor

Studies

Medical Science Course

Metabolic
Control
System


Cellular and Molecular
Physiology
iPhysiology Ij

Hiroko Matsuda

‚P@Structure and function of K channels

‚Q@Functional analysis of neuronal ion channels and receptors

‚R@Synaptic plasticity

‚S@Intracellular transport of membrane proteins

Molecular Functional
Biology
(Medical Chemistry)

Seiji Ito

‚P@Biochemistry and molecular biology in health and diseases

‚Q@Identification and characterization of functional molecules involved in neural plasticity

‚R@Molecular functional biology of behavior and signal transduction using knockout mice

Molecular Pharmacology
(Pharmacology)

Tomoyuki Nakamura

‚P@Molecular mechanism of elastogenesis

‚Q@Biological function of carbohydrate chains

‚R@Dynamic molecular mechanisms of intracellular Cl| concentration in CNS neurons

‚S@Pathophysiological roles of protease-activated receptor in cardiovascular system

Cell Biology
(Biology)

Yasuaki Yoshimoto

‚P@Mechanism of cell movement

Regulation and mechanism in various types of intracellular streaming and amoeboid movement

‚Q@Mechanism of cell division

Regulation and mechanism of cleavage furrow formation in various types of egg cells

‚R@Visualization of Ca2{ signals

Visualization of Ca2{ signals at fertilization and cleavage

Visualization of Ca2{ signals in various types of cell movement

Biochemistry
(Chemistry)

Shigeru Fujii

‚P@NMR study on structures and functions of biomolecules

‚Q@Protein structures and reaction mechanisms of flavoenzymes

‚R@Structures and functions of sugar chains in
glycoproteins

Biophysics
(Physics)

Hiroshi Kihara

‚P@Biophysics

‚Q@Dynamic study on structure and function of proteins

‚R@Biomedical application of x-ray microscopy

‚S@Protein folding

Health
Science

Yutaka Kimura

‚P@Psychological and metabolic effects of exercise

‚Q@Obesity research by eating behavioral science

‚R@Antiaging research for antioxidation

‚S@Behavior modification by Telemedicine

‚T@Life style related disease intervention with medical information network


Cardiology,
Nephrology,
Endocrinology and Metabolism

(Internal Medicine II)

Toshiji Iwasaka

Mitsushige Nishikawa

‚P@Experimental study of heart failure

‚Q@Molecular biology of ischemic heart disease

‚R@Clinical study of hemodynamic and coronary circulation in ischemic heart disease

‚S@Exercise therapy for the patients with heart disease

‚T@Clinical study of hypertension and arterial sclerosis

‚U@Biomedical approach of congenital diabetes insipidus

‚V@Research for Basedow disease

‚W@Research for diabetes and diabetic nephropaty

‚X@Research for aging and endocrinology

10@Research for diabetic cardiomyopaty

11@Research for gene expression of thyroxine enzyme

12@Gene expression of catecholamine receptor of vascular smooth muscle

13@Research for the relation between pregnancy and thyroid function

14@Research for hemodialysis and hemofiltlation

15@Research for renal disease


Gastroenter-
ology and Hepatology

(Internal Medicine III)

Kazuichi Okazaki

‚P@Analysis of hepatocyte function

‚Q@Drug metabolism

‚R@Viral hepatitis

‚S@Immune response

‚T@Hemodynamics

‚U@Mucosal metabolism

‚V@Tumor staging

‚W@Barrier breaker

‚X@Helicobacter pyroli infection

10@Screlo therapy

11@Pancreatiits hemodynamism

12@Biliary thract imaging

13@TGF-beta signal transduction

14@Autoimmune pancreatitis

15@Inflammatory bowel disease

™›
Surgery

Masanori Kon

‚P@Diagnosis and treatment of hepato-biliary-pancretic cancer

‚Q@Liver regeneration and pathophysiology of the liver

‚R@Artificial liver

‚S@Organ preservation and transplantation

‚T@Diagnosis and treatment of peripheral vascular diseases

‚U@Clinical oncology

‚V@Carcinogenesis and chemoprevention

‚W@Surgical metabolism

‚X Diagnosis and treatment of breast cancer

10 Pathophysiology of digestive diseases

11 Pediatric surgery


Thoracic and Cardiovascular Surgery

Naoki Minato

‚P@Basic research for cardiac and lung

‚Q@Clinical and experimental studies of myocardial protection

‚R@Immunological and biological studies of the freezed allograft

‚S@Immunological and surgical studies for the treatment of lung cancer

‚T@Surgical strategy for chronic respiratory disease

‚U@Immunological studies for mediastinal tumor

™›
Obstetrics and Gynecology

Hideharu Kanzaki

‚P@Gynecologic Oncology

‚Q@Reproductive Endocrinology

‚R@Molecular and Cellular Biology of Human Endometrium

‚S@Local Immune System in Human Endometrium

‚T@Molecular and Cellular Biology of Uterine Contraction

‚U@Basic and Clinical Study for Implantation Failure

™›
Department of Clinical Sciences and Laboratory Medicine

Hakuo Takahashi

‚P@Vasoactive substances and the roles in hypertension

‚Q@Studies on central regulation of blood pressure

‚R@Endocrinological studies on hypertension

‚S@Diagnostic roles of humoral factors for assessment of atherosclerotic vascular diseases

‚T@Non-invasive procedures for assessment of peripheral circulation

‚U@Pathophysiological studies on hemostasis

™›
Emergency and
Critical Care
Medicine

Toshio Nakatani

‚P@Traumatology, Critical Care Medicine

‚Q@Clinical Toxicology

‚R@Clinical and experimental studies on bodily responses under stress situationiex.Responses to the stress in schizophrenic patientsj

‚S@Metabolic changes in stress situation

Integrative
Biosystem

Anatomy and
Cell Science

(Anatomy I)

Hisao Yamada

‚P@Effects of brain-vascular peptides and interaction among neural-^endothelial-^leptomeningeal-cells

‚Q@Morphogenesis, remodeling, regeneration of peripheral nervous system in the pancreas and intestine

‚R@Cell science on endoplasmic reticula and mitochondria

‚S@Methodological developement and improvement of quantitative and^or molecular histocytochemistry and functional analysis for cell-science

Anatomy and
Brain Science

(Anatomy II)

Tetsuo Sugimoto

‚P@Receptors and ion channels: cloning, expression and functional analysis in brain

‚Q@CNS and PNS: search for neuronal connectivity

‚R@Functional neuroanatomy of basal ganglia and several chemospecific pathways

‚S@Gene knock-outs: their use in studies of novel neuronal messengers

Cognitive Neuroscience
(Physiology II)

Kae Nakamura

‚P@Neural basis of decision making, learning and memory

‚Q@Electrophysiological approach of the central nervous system

ž›
Neurology

Hirofumi Kusaka

‚P@Clinical and pathological researches of neurological disorders

‚Q@Neuroimaging studies of neurodegenerative diseases

‚R@Molecular biology of neurodegenerative diseases

‚S@Neuropathological researches of neurodegeneration

‚T@Neuroimmunological studies of neuromuscular disorders

‚U@Pathological and molecular biological researches of neuromuscular disorders

‚V@Pathophysiology and Therapeutics of Parkinson disease and clinical application of stereotacitic surgery

‚W@Pathomecanism of motor neuron diseases

™›
Neurosurgery

Keiji Kawamoto

‚P@Molecular research and therapy for malignant brain tumors

‚Q@Research for fine structure of brain lesions

‚R@Clinical study of endovascular neurosurgery

‚S@Developmental research for central nervous system anomaly

‚T@Basic and clinical study of skull base surgery

‚U@Genetic therapy of brain tumors

‚V@Neuronal regeneration of brain lesions by bone marrow transplantation

‚W@Study on judgment of brain death by using nasal EEG leads

‚X@Morphological analysis of skull by 3DCT


Orthopedic Surgery

Hirokazu Iida

‚P@Clinical and basic research of the bone and joint diseases

‚Q@Clinical and basic research of the spinal disorders

‚R@Electorophysiologic analyses of the central and peripheral nerve disorders

‚S@Clinical and basic research of the hand surgery

™›
Plastic and Reconstructive Surgery

Kenji Kusumoto

‚P@Wound healing in skin and soft tissues

‚Q@Pathologic physiology of hypertrophic scar and keloid

‚R@Study of regeneration of skin, soft tissue, cartilage and bone

‚S@Organ transplantation of skin, soft tissue, cartilage and bone

‚T@Pathologic physiology of skin flaps

‚U@Study of cranio-maxillofacical growth and deformities

™›
Anesthesiology

Koh Shingu

‚P@Development of tolerance with central effecting drugs

‚Q@Biochemical investigation of central effects of anesthetics

‚R@Studies of methods for airway management

ž›
Otolaryngology

Koichi Tomoda

‚P@Physiology, biochemistry and immunology of inner ear

‚Q@Physiology of middle ear and tubal function

‚R@Physiological and clinical study of allergic rhinitis

‚S@Fundamental and clinical study of head and neck tumor

‚T@Fundamental study of autonomic nerve in head and neck

‚U@Genetic molecular biology of inner ear and head and neck tumor

™›
Ophthalmology

Kanji Takahashi

‚P@Pathopysiology of chorioretinal disease

‚Q  Pathopysiology of vitreoretinal disease

‚R@Pathopysiology of intraocular circulatory disorder

‚S@Basic and clinical research of intraocular inflammation

‚T@Pathopysiology of optic nerve disease

‚U@Basic and clinical research of aqueous outflow resistance

Biological
Response

Stem Cell Pathology
(Pathology I)

Hiroo Ueno

‚P@Identification of tissue specific stem cells

‚Q@Mechanisms of maintenance of intestinal stem cells

‚R@Pathogenesis of colon cancer

‚S@Analysis of germ cell development

‚T@Induction of tissue specific stem cells by reprogramming factors

Comparative Pathology
(Pathology II)

Airo Tsubura

‚P@Cancer chemoprevention

‚Q@Establishment of animal models for human disease

‚R@Analysis of mammary carcinogenesis due to murine mammary tumor virus

‚S@Analysis of gene alterations in carcinogenesis

‚T@Immunohistochemical analysis of tumor cell phenotype

‚U@Ultrastructural observations of tissue and cell

iNotejWe desire persons who are interested in human as well as experimental pathology

Microbiology

Jun-ichi Fujisawa

‚P@Modulation of cellular functions by regulatory factors of human retroviruses

‚Q@Analysis of the early phase of infection by human retroviruses

‚R@Development of DNA vaccine against infectious diseases and cancers

‚S@Development of virus vectors for gene therapy

Molecular
Immunology
(Molecular Genetics)

Tatsuo Kinashi

‚P@Regulation of integrin-dependent adhesion of immune cells by small GTPase Rap‚Psignaling

‚Q@Study of signal transduction regulating lymphocyte homing


Hematology,
Respiratory Medicine
and Rheumatology
(Internal Medicine I)

Shosaku Nomura

‚P@Research for the mechanism of hematologic and respiratory diseases

‚Q@Research for the mechanism of collagen diseases

‚R@Research for the mechanism and control of host defense

‚S@Research for the mechanism of thrombosis and hemostasis

‚T@Research for the mechanism and control of hematologic malignancy and lung cancer

‚U@Research for hematopoietic stem cells transplantation iHSCTj

‚V@Research for the mechanism and control of immunotherapy

š›
Pediatrics

Kazunari Kaneko

‚P@Role of reactive oxygen species in children with diverse condition

‚Q@Relationship between intracellular magnesium ^calcium and insulin resistance in children

‚R@Role of renin-angiotensin in immunoregulatory system

‚S@Serum BNPibrain natriuretic peptidej in neonatal period

‚T@Role of nitric oxide iNOj in childhood kidney diseases

‚U@Development of induction for oral tolerance in children with food allergy

™›
Dermatology

Hiroyuki Okamoto

‚P@Skin allergology and immunology

‚Q@Photobiology

‚R@Action mechanisms of photochemotherapy

‚S@Mechanisms of photocarcinogenesis

‚T  Mechanisms of granuloma formation


Urology

Tadashi Matsuda

‚P@Basic and clinical research on male gonadal function

‚Q@Clinical research on urologic laparoscopy

‚R@Urologic microsurgery

‚S@Basic and clinical research on genitourinary tumor

š›
Radiology

Satoshi Sawada

‚P@Investigation in interventional radiology

‚Q@Radionuclid evaluation of the organ function

‚R@Study for the relationship between radiosensitivity and oncogene expression

‚S@Investigation in three dimensional images

‚T@Study for fusion imagings

‚U@Study of new applications of high dose rate brachitherapy

Social
Environmental
Medicine

Life Science
of Environmental
and Preventive
Medicine

(Hygieiology)

Yoshiaki Sonoda

‚P@Study of selective estrogen receptor modulator

‚Q@Mechanisms of occupational intoxication by heavy metals and organic compounds

‚R@Experimental study of energy restriction and pathophysiology

Public Health
and
International Health

Toshimasa Nishiyama

‚P@Study of infection and preventive medicine

‚Q@Study international health and medicine

‚R@Study of environmental endocrine disruptors

‚S@Study of health management for overseas travelers

‚T@Study of travel vaccine

‚U@Study of aged care

Forensic Science
and Bioethics

Atsushi Akane

‚P@DNA analysis of polymorphic genetic markers

‚Q@Microanalysis of biochemical markers and drugs in biological specimens

‚R@ibliographical analysis of bioethical topics

Biostatistics
(
Mathematic)

Shigeru Maeda

‚P@Statistical Analysis of Clinical Data

‚Q@Mathematical Analysis of Medical Diagnostics and Clinical Control


Medical Informatics
(Information Center)

Jun Watanabe, Associate Professor

‚P@Research and development of arcitecture,construction, and management of medical information systems

‚Q@Studies on security for wired and wireless networking systems

‚R@Studies on the relationship between information systems and medical care for community

‚S@Research and development of medical information systems with open source codes

‚T@Studies on the standardization of medicalterminology for medical information systems

™›
Bio-psycho-social
Medicine

(Psychosomatic Medicine)

Mikihiko Fukunaga

‚P@Multidisciplinary Study on Body-Mind Relations of Gastrointestinal disorder

‚Q@Study on Psychosocial Perspectives of Chronic Pain Syndrome

‚R@Psycho-Oncological Multidisciplinary Study on the Patients with Cancer

‚S@Study on Evidence of Complementary-Alternative Medicine

™›
Neuropsychiatry

Toshihiko Kinoshita

‚P@Research for neuroimaging

‚Q@Research for neuropathology

‚R@Research for psychopharmacology

‚S@Research for quantitative pharmaco-EEG

‚T@Research for consultation-liaison psychiatry

‚U@Research for child and adolescent psychiatry

‚V@Research for epilepsy

‚W@Research for geriatric dementia

‚X@Research for epidemiology of mental disorders

Advanced Medicine Course

Regeneration Medicine

Regenerative Pathology
(Pathology I)

Hiroo Ueno

‚P@Development of new strategies for regenerative medicine of various tissues (heart, intestine,lung, liver, pancreas, adrenal glands, bone,cartilage, and so on)

‚Q@Application of purified tissue specific stem cells to regenerative medicine

‚R@Application of induced tissue specific stem cells to regenerative medicine

Molecular
Immunopathology

(Molecular Genetics)

Tatsuo Kinashi

Study of immune surveillance by genetic engineering of trafficking-related genes

Viral Oncology
(Microbiology)

Jun-ichi Fujisawa

‚P@Mechanism of cellular transformation by human T-cell leukemia virus

‚Q@Development of ATL model mouse system

‚R@Development of prevention and curative therapy against ATL

Stem Cell Biology
(Hygieiology)

Yoshiaki Sonoda

‚P@Purification of hematopoietic stem cells and investigation of stem cell characteristics

‚Q@Investigation of plasticity of somatic stem cells and their clinical application

‚R@Identification of specific genes expressed on hematopoietic stem cells

‚S@Development of translational research using human tissue committed stem cells

‚T@Development of new stem cell transplantation method and^or regenerative medicine using the intra-bone marrow injection technique


Cellular Immunotherapy
(Internal Medicine I)

Shosaku Nomura

‚P@Immunobiology of malignant neoplasm

‚Q@Immunobiology of inflammatory diseases

‚R@Isolation and amplification of effector cells for immunotherapy


Regenerative Medicine
(Therapeutic Angiogenesis)
(Internal Medicine II)

Toshiji
Iwasaka

Mitsushige Nishikawa

‚P@Regenerative medicine for cardiovascular disease

‚Q@Cell implantation for Diabetic peripheral neuropathy


Regenerative Medicine of
the
Digestive
Organsand Liver

(Internal Medicine III)

Kazuichi Okazaki

‚P@Autoimmune pancreatitis

‚Q@Inflammatory bowel disease

š›
Restoration of Cellular
Functions

(
Pediatrics)

Kazunari Kaneko

‚P@Chemotaxis of neutrophils and eosinophils from neonates using new equipment

‚Q@A novel role of eosinophils: phagocytosis and bacterial killing

‚R@A new therapeutic strategy for chronic granulomatous disease iCGDj:intra-bone marrow injection of the bone marrow cells into mouse model of CGD

‚S@Functional analysis of the mutated CXCR4 protein of WHIM syndrome icombined immunodeficiency diseasej

‚T@Regeneration of kidney in mouse model of Nephrotic syndrome

™›
Tissue Repairing,
Regeneration,
Organ Transplantation

(Surgery)

Masanori Kon

‚P@Repairing of Tissue and Organ

‚Q@Regeneration of Tissue and Organ

‚R@Bone Marrow Transplantation for Solid Tumors


Regeneration of
Cardiomyocyte and
Cellular Transplantation

(Thoracic and Cardiovascular Surgery)

Naoki Minato

‚P@Therapeutic angiogenesis for patients with ischemic heart disease

‚Q@Regeneration of cardiomyocyte and cellular transplantation therapy

‚R@Molecularbiological studies for cardiac preservation

‚S@Gene therapy for pulmonary hypertention

™›
Reproductive Medicine
for Female Infertility
Treatment

(Obstetrics and Gynecology)

Hideharu Kanzaki

Study on human endometrial stem cells for the treatment of implantation failure


Regenerative Medicine
for
Osteocartilaginous
Tissue

(Orthopaedic Surgery)

Hirokazu Iida

‚P@Development of a new method for steroid-induced osteonecrosis of the femoral head using bone marrow cells

‚Q@Development of a new method for autoimmune diseases using intra-bone marrow injection

‚R@Regeneration of nucleus pulposus cells by bone marrow cells

™›
Skin and Soft
Tissue
Regenerative Medicine
(Plastic and Reconstructive Surgery)

Kenji Kusumoto

‚P@Wound healing in skin and soft tissue

‚Q@Regeneration of skin, soft tissue, cartilage and bone controlling differentiation mechanisms


Kidney Transplantation
(Urology)

Tadashi Matsuda

‚P@Induction of immune tolerance in kidney transplantation

‚Q@Development of minimally invasive donor nephrectomy

Medical Neuroscience

Regenerative Neural
Medicine

(Anatomy I)

Hisao Yamada

‚P@Derivation and characterization of neural stem^progenitor cells

‚Q@Cell-proliferation, -differentiation, -death, and cell-renewal in the neural tissues

‚R@Function and histochemical structure of neuroendocrine system

Molecular Research
for
Neural Regulation
and Disease

(Anatomy II)

Tetsuo Sugimoto

‚P@Neurological and psychiatric disorders: system and neuropharmacological approach

‚Q@Neurobiology of the movement disorders

Neurobiology of higher
Congnitive Function

(Physiology II)

Kae Nakamura

‚P@Neurological and psychiatric disorders: system and neuropharmacological approach

‚Q@Neurobiology of the movement disorders

Medical science
for Pain
(Medical Chemistry)



Seiji Ito

‚P@Generation, maintenance and cognition of chronic pain and nerve regeneration

‚Q@Molecular imaging in neuroscience

‚R@Proteomics and genomics

Neuropharmacology
(Pharmacology)

Tomoyuki Nakamura

‚P@Alzheimer's disease; development of therapeutics using model mice

‚Q@Molecular mechanisms of amyloid beta neurotoxicity

Neurotoxic Control
(Pathology II)

Airo Tsubura

Suppression of neural damage against neurotoxic substances

Regenerative
Medicine for
Neuronal and
Endocrine Functions

(Public Health)

Toshimasa Nishiyama

‚P@Study for differentiation of multipotential stem cells into ectodermal cells

‚Q@Molecular function of tissue specific stem cells

™›
Human Stress
Medicine
^
Behavioral Medicine

(Psychosomatic Medicine)

Mikihiko Fukunaga

‚P@Stress response analysis with Multi-channel Psycho-Physiological recording

‚Q@Methodological Study of Clinical Assessment by the Biopsychosocial Medical Model

‚R@Cognitive Behavioral Study of Biofeedback Therapy

ž›
Intractable
Neuromuscular
Disease
Research
(Neurology)

Hirofumi Kusaka

‚P@Nerve cell degeneration and regeneration ianimal model of motor neuron diseasej

‚Q@Basic research for signal transmission in the muscle cell iregeneration of musclej

‚R@Plasticity of the hasal ganglia neural circuits

ž›
Regenerative
Medicine of
Auditory Function
(Otolaryngology)

Koichi Tomoda

‚P@Regeneration of inner ear hair cell

‚Q@Bone marrow transplantation

‚R@Gene transfer to inner ear

™›
Visual Science
(Ophthalmology)

Kanji Takahashi

‚P@Degeneration and regeneration of retinal neurons

‚Q@Suprression of intraocular neovascularization and vascular regeneration

™›
Brain-Mind Research
(Neuropsychiatry)

Toshihiko Kinoshita

‚P@Research for optimal pharmacotherapy with pharmacogenetics

‚Q@Neuroimaging study of pathophysiology of mental disorders

‚R@Research for optimal pharmacotherapy with pharmaco|EEG


Neuroreconstructive
Surgery

(Neurosurgery)

Keiji Kawamoto

‚P@Molecular research and therapy for malignant brain tumors

‚Q@Neuronal regeneration of brain lesions by bone marrow transplantation

‚R@Developmental research for central nervous system anomaly

‚S@Research for fine structure of brain lesions

™›
Medical Control of
Stress Response

(Anesthesiology)

Koh Shingu

‚P@Central effects of anesthetics

‚Q@Response to noxious stimuli and their modulation by anesthetics

‚R@Percutaneous placement of an epidural catheter in a rabbit and its application for epidural administration of drugs

‚S@Pain control with subarachnoidal administration of steroids

™›
Spinal Cord Regeneration
(Emergency and Critical Care Medicine)

Toshio Nakatani

‚P@Traumatology, Critical Care Medicine

‚Q@Clinical and experimental studies on regeneration of spinal cord injury